Collaborative Approaches to the Clinical High Risk State: From Data to Mechanism to Intervention

For decades now, schizophrenia has been clearly understood as a disorder of neurodevelopment that is biologically manifest long before symptoms of frank psychosis. This realization led to efforts to understand the pathophysiological processes that precede psychosis, efforts which have lately come to fruition thanks to the study of the clinical high risk (CHR) state. CHR studies represent a unique opportunity for secondary prevention in psychiatry, i.e., an opportunity to intervene in the mechanisms that drive a disease process, thereby altering the course of illness and facilitating true recovery.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research