GSE150856 C. albicans white-opaque transcription factor binding recorded in the mammalian gut

Contributors : Jessica N Witchley ; Suzanne M NobleSeries Type : OtherOrganism : Candida albicansCandida albicans is a central fungal component of the human gut microbiota and an opportunistic pathogen. Two C. albicans transcription factors, Wor1 and Efg1, control its ability to colonize the mammalian gut. They are also master regulators of an epigenetic switch required for mating. The mammalian gastrointestinal tract is a complex environment difficult to model in vitro. In C. albicans, it is known that environmental signals can dictate the binding targets of these transcription factors. To study the regulation of transcription factors of C. albicans in the GI tract, a Calling card-seq approach was adopted. This technique allowed us to directly record transcription factor binding that occurred in the mammalian gut.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Candida albicans Source Type: research