A TOMM40/APOE allele encoding APOE ‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases

ConclusionThe striking association ofTOMM40 only with high likelihood AD may explain some contrasting results forTOMM40 in clinical studies and may reflect an association with more advanced disease and/or suggest a role ofTOMM40 in the pathogenesis of neurofibrillary tangles.

Source: Molecular Genetics & Genomic Medicine - May 29, 2020 Category: Genetics & Stem Cells Authors: Selma M. Soyal, Markus Kwik, Ognian Kalev, Stefan Lenz, Greta Zara, Peter Strasser, Wolfgang Patsch, Serge Weis Tags: ORIGINAL ARTICLE Source Type: research