GSE133394 Gene expression analysis of treatment-na ïve hormone receptor-positive metastistic breast cancer

Contributors : Liu Yuan ; Zhu ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to letrozoleCyclin-dependent kinase 4/6 (CDK4/6) inhibitors have demonstrated significant activity in estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) advanced breast cancer. Further biomarkers to refine the population beyond ER+/HER2- that benefits remain to be identified. We performed a comprehensive biomarker analysis using patient tissues from PALOMA-2, a randomized phase 3 study of palbociclib-letrozole versus placebo-letrozole, to determine markers of sensitivity and resistance to the combination.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research