Radiobiologically-derived bi-phasic fractionation schemes to overcome the effects of tumour hypoxia.

CONCLUSION: In hypoxic tumours, novel fractionation strategies result in significantly higher tumour BED in comparison to conventional fractionation.
ADVANCES IN KNOWLEDGE: We demonstrate that novel bi-phasic fractionation regimens could overcome the effects of tumour hypoxia resulting in biological dose escalation.
PMID: 32462907 [PubMed - as supplied by publisher]

Source: The British Journal of Radiology - May 27, 2020 Category: Radiology Authors: Joseph N, Kirkby NF, Hoskin PJ, West CML, Choudhury A, Dale RG Tags: Br J Radiol Source Type: research