< i > Lin28a/let-7 < /i > pathway modulates the < i > Hox < /i > code via < i > Polycomb < /i > regulation during axial patterning in vertebrates

In this study, we demonstrated that theLin28a/let-7 pathway is critical for axial elongation.Lin28a–/– mice exhibited axial shortening with mild skeletal transformations of vertebrae, which were consistent with results in mice with tail bud-specific mutants of Lin28a. The accumulation oflet-7 inLin28a–/– mice resulted in the reduction of PRC1 occupancy at theHox cluster loci by targetingCbx2. Consistently, Lin28a loss in embryonic stem-like cells led to aberrant induction of posteriorHox genes, which was rescued by the knockdown oflet-7. These results suggest that theLin28/let-7 pathway is involved in the modulation of the ‘Hox code ’ viaPolycomb regulation during axial patterning.
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Source Type: research