The viral suppressor HCPro decreases DNA methylation and activates auxin biosynthesis genes.

In this study, we investigated the molecular mechanism by which helper-component protease (HCPro) encoded by the Tobacco vein banding mosaic virus (TVBMV) activates auxin biosynthesis genes (YUCs) and interferes with the auxin signaling pathway. Our results demonstrated that the viral suppressor HCPro decreased the DNA methylation of dispersed repeats (DRs) within the promoters of YUC1, YUC5 and YUC10 and transcriptional activated these YUC genes targeted by RNA-directed DNA methylation (RdDM), leading to an increase in auxin accumulation in plants. Furthermore, we found that the induction of these YUCs by HCPro was attenuated in ros1 mutant plants, suggesting that HCPro-mediated transcriptional activation of the genes was partly dependent on ROS1-mediated DNA demethylation. PMID: 32452413 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32452413?dopt=Abstract

Source: Virology - May 28, 2020 Category: Virology Authors: Yang L, Meng D, Wang Y, Wu Y, Lang C, Jin T, Zhou X Tags: Virology Source Type: research