Neurophysiological changes after cognitive-motor tasks in Parkinson's disease patients with deep brain stimulation.

Neurophysiological changes after cognitive-motor tasks in Parkinson's disease patients with deep brain stimulation. Funct Neurol. 2019 Jul/Sep;34(3):177-187 Authors: Negri M, Gorgora M, Nasser JA, Salles JI, Teixeira S, Arias-Carrión O, Junqueira J, Nicoliche E, Velasques B, Cagy M, Budde H, Basile LF, Orsini M, Friede R, Bastos VH, Ribeiro P Abstract Chronic deep brain stimulation (CDBS) is a surgical treatment that reduces the cardinal signs of Parkinson's disease (PD). Although CDBS has been in use for a long time, very little has been reported on its supposed effects on cognition, particularly in relation to implants in the subthalamic nucleus. The results of the rare studies that do exist are controversial, and in many cases the studies have several design flaws. The present study compared cortical activation during three tasks (action execution, action observation and motor imagery) in PD patients with and without subthalamic implants. The study sample consisted of 36 volunteers, divided into three groups: healthy controls, PD patients with CDBS of the subthalamic nucleus, and PD patients without CDBS. Through a quantitative electroencephalogram assessment, absolute beta power was examined to observe the interaction between group and cognitive motor tasks. The electrodes at sites Fp1, Fp2, F7, F8, F3, Fz and F4, located in the prefrontal and frontal regions, were analyzed and a Group x Task interaction (p
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

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Deep brain stimulation (DBS) has significant effects on motor symptoms in Parkinson's disease (PD), but existing studies on the effect of DBS on speech are rather inconclusive. It is assumed that deficits in auditory-motor integration strongly contribute to Parkinsonian speech pathology. The aim of the present study was to assess whether subthalamic DBS can modulate these deficits. Twenty PD patients (15 male, 5 female; 62.4 ± 6.7 years) with subthalamic DBS were exposed to pitch-shifted acoustic feedback during vowel vocalization and subsequent listening. Voice and brain activity were measured ON and OFF stimulatio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we examined the effects of unilateral DBS-STN applied in male Wistar rats wit h 6-hydroxydopamine PD model (DBS-6OHDA) and rats without nigral dopamine depletion (DBS) on corticosterone (CORT) plasma concentration, blood natural killer cell cytotoxicity (NKCC), leukocyte numbers, lymphocyte population and apoptosis numbers, plasma interferon gamma (IFN-γ), interleukin 6 (IL- 6), and tumor necrosis factor (TNF-α) concentration. The same peripheral immune parameters we measured also in non-stimulated rats with PD model (6OHDA). We observed peripheral immunity changes related to PD model. The NKCC a...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsOur findings indicate a relatively high rate of suicidality among Parkinson ’s patients after subthalamic nucleus deep-brain stimulation. It is important for clinicians to carefully monitor psychiatric disorders, especially suicidal ideation and suicide attempts, in Parkinson’s patients before and after subthalamic nucleus deep-brain stimulation.
Source: Neurological Sciences - Category: Neurology Source Type: research
ConclusionsFrameless stereotaxy is an effective and safe technique for DBS surgery at 1- and 3-year follow-up, with great advantages for patients ’ discomfort during surgery.
Source: Neurological Sciences - Category: Neurology Source Type: research
Caregiver burden (CB) in Parkinson's disease (PD) does not improve in the short term after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS), despite motor improvement. This may be due to increased caregiver demands after surgery or the possibility that DBS unresponsive non-motor factors, such as executive dysfunction, contribute to CB.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Freezing of gait (FOG) is a devastating symptom of Parkinson ’s disease (PD), affecting over half of the patient population [1] and negatively impacting mobility and patient quality of life. This symptom has been difficult to treat with dopaminergic medication, is associated with arrhythmic gait, and can become refractory over time [2]. Moreover, it is deba ted to what extent deep brain stimulation (DBS) provided in an open-loop manner (olDBS) can mitigate FOG [3].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Background: Modeling of deep brain stimulation electric fields and anatomy-based software might improve post-operative management of patients with Parkinson's disease (PD) who have benefitted from subthalamic nucleus deep brain stimulation (STN-DBS).Objective: We compared clinical and software-guided determination of the thresholds for current diffusion to the pyramidal tract, the most frequent limiting side effect in post-operative management of STN-DBS PD patients.Methods: We assessed monopolar reviews in 16 consecutive STN-DBS PD patients and retrospectively compared clinical capsular thresholds, which had been assessed...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The aim of this study was to compare the short- and long-term outcomes of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients with and without probable REM sleep behavior disorder (RBD).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
Resting tremor is one of the major symptoms of Parkinson’s disease, which causes havoc in motor functions of the body, has its genesis in communication impairments in the subthalamic nucleus of the basal ganglia. The modern sophisticated surgical treatments, including electrical deep brain stimulation do not yield satisfactory results due to their inability to provide long-term cure and minimize side effects, such as discomfort and increased infection rates. In this work, we propose a novel system based on the emerging communication technology of wireless optogenetic networks of neural dusts to provide a long-term so...
Source: IEE Transactions on NanoBioscience - Category: Nanotechnology Source Type: research
Abstract The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, open-loop DBS applications are incapable of modifying parameters in real time to react to fluctuations in disease states. Thus, current practice for the designation of stimulation parameters, such as duration, amplitude, and pulse frequency, is an algorithmic process. Ideal stimulation parameters are highly individualized and must reflect both the specific disease presen...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
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