Natural soluble human leukocyte antigen class I in donor serum neutralizes donorspecific HLA alloantibodies in recipient serum.
Conclusions: Using inhibition FCXM, we verified that natural sHLA class I in donor serum neutralizes DSAs in recipient serum. However, no neutralizing effects of sHLA class II were revealed in this study. These potentially beneficial effects of sHLA infused via blood-derived products should be considered when desensitizing highly HLA-sensitized patients.
PMID: 32429622 [PubMed - as supplied by publisher]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
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