Exclusive Enteral Nutrition Formulas Used in Crohn's Disease Exclusive Enteral Nutrition Formulas Used in Crohn's Disease
This study analyzed nonnutrient food ingredients and food additive composition of EEN formulas.Alimentary Pharmacology &Therapeutics
In this study, we further explored the effect of sucralose on tumorigenesis and the possible mechanism involved using the AOM/DSS mouse model. First, 1.5 mg/ml sucralose was included in the drinking water for 6 weeks to reach a relatively stable phase of impact on gut microbiota. Then, 10 mg/kg AOM was administered through intraperitoneal injection. Seven days later, 2.5% DSS was put in the drinking water for 5 days, followed by 2 weeks without DSS. The 5 days of DSS was then repeated, and the mice were sacrificed 6 weeks after AOM injection. The results showed that sucralose caused significant increases in the number and ...
Add “improving” before “detection”? PET/MR is beneficial particularly in pediatric patients who undergo recurrent imaging, such as those with cancer or chronic inflammatory disease. PET/MR has advantages compared with PET/computed tomography, including decreased radiation exposure and superior c haracterization of soft tissue. Ongoing challenges include reducing examination duration and costs and detection of pulmonary lesions. Accepted clinical applications of PET/MR in pediatric patients are evaluation of epileptic foci and diagnosis, staging, and follow-up of solid tumors. PET/MR also ma y have a...
Contributors : Fatemeh Adiliaghdam ; Sreehaas Digumarthi ; Lai P Wong ; Ruslan Sadreyev ; Kate L JeffreySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeripheral blood-derived macrophages were stimulated with viral-like particles isolated from colonic resections from patients with Crohn's disease (CD), ulcerative colitis (UC), or non-IBD controls diagnoses. RNAseq was performed to unbiasedly assess the transcriptional responses to these stimuli and revealed highly divergent macrophage transcriptional programs in response to non-IBD compared to IBD VLP.
Publication date: Available online 30 May 2020Source: European Journal of RadiologyAuthor(s): L. Tkalčić, Kaštelan Z. Matana, T. Grubešić, Sinčić B. Mijandrušić, S. Milić, D. Miletić
Ileocolonic resection is the most common surgery in Crohn's disease (CD). However, stricture formation in the anastomosis is considered to be a frequent cause of significant morbidity in CD and a reason for reoperation. Endoscopic balloon dilation (EBD) is an established modality for non-surgical treatment of strictures in CD, however, summary data from the Czech Republic are lacking.
Rates of surgical intervention in Crohn ’s disease have declined. However, a significant proportion of patients still require surgical resection and have been shown to have higher post-op pain scores and analgesia requirements. The aim of this study was to assess sedation requirements and comfort scores of post-operative Crohn’s disea se patients at endoscopy.
Strictures, both primary and secondary anastomotic strictures, are common complications in patients with inflammatory bowel diseases (IBD) especially Crohn's disease (CD). Balloon dilation has been the gold standard in the endoscopic treatment of these strictures. Endoscopic stricturotomy (ESt) represent a promising novel approach, however, the data published on this method so far is limited to a single US center.
Endoscopic assessment of disease activity is an essential part of clinical practice in inflammatory bowel disease (IBD) and is used for diagnosis, prognosis, monitoring for dysplasia and increasingly for the evaluation of mucosal or endoscopic response to therapy. Recently, endoscopic healing has emerged as a key goal of therapy However there are numerous endoscopic scoring systems proposed to define endoscopic activity and response to therapy in both ulcerative colitis and Crohns disease. The routine use of endoscopic scoring systems is currently limited to trial settings.
In order to improve the postoperative course of patients with Crohn ’s disease (CD), it is important to optimize the postoperative medical treatments based on scheduled assessments of the endoscopic activity. However, there are insufficient data about the endoscopic activity of small bowel lesions that are common in patients with CD. We aimed to assess the postope rative activity of small bowel lesions using capsule endoscopy (CE), and to analyze the association between the treatment optimization based on the postoperative endoscopic activity and the subsequent course.