The impact of long-term alcohol consumption and relapse on genome-wide DNA methylation changes in alcohol-dependent subjects: a longitudinal design.

CONCLUSION: Although the present study represents the largest study of methylation levels in a sample of AUD patients with a follow up period of one year and accounting for alcohol consumption and relapse to date, the sample size might still not be large enough to detect genome-wide significant effects. Therefore, large-scale, long-term studies with AUD subjects are needed to determine the utility of DNA methylation for the assessment and monitoring of persons with alcohol use disorders. PMID: 32419198 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research