Prevalence, Incidence, and Impact on Mortality of Conduction System Disease in Transthyretin Cardiac Amyloidosis

Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized infiltrative cardiomyopathy in which conduction system disease is common. The aim of our study was to define the incidence and prevalence of high-grade atrioventricular (AV) block requiring pacemaker implantation in our quaternary referral center. This was a single-center retrospective cohort study of 369 consecutive patients with ATTR-CA who underwent 12-lead electrocardiogram (ECG) at the time of ATTR-CA diagnosis. During a mean follow-up of 28 months, serial ECGs and the electronic medical record were examined for the development of high-grade AV block and pacemaker implantation.

Source: The American Journal of Cardiology - May 15, 2020 Category: Cardiology Authors: Eoin Donnellan, Oussama M Wazni, Walid I Saliba, Mazen Hanna, Mohamed Kanj, Divyang R Patel, Bryan Wilner, Arshneel Kochar, Wael A Jaber Source Type: research