Crosslinker concentration controls TGF β-3 release and annulus fibrosus cell apoptosis in genipin-crosslinked fibrin hydrogels.

In conclusion, FibGen could be used for delivering biologically active compounds and AF cells, provided that formulations supplied additional sites for cell-biomaterial binding and genipin concentrations were low. Results also highlighted a need for developing strategies that protect cells against acute crosslinker cytotoxicity to overcome challenges of engineering high-modulus cell carriers for musculoskeletal tissues that experience high mechanical demands. PMID: 32396210 [PubMed - in process]
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research