Protein and antibody engineering - suppressing degranulation of the mast cells and type I hypersensitivity reaction.

Protein and antibody engineering - suppressing degranulation of the mast cells and type I hypersensitivity reaction. Curr Protein Pept Sci. 2020 May 10;: Authors: Rajani HF, Shahidi S, Gomari MM Abstract With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen . Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to move to improve the clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells, in order to regulate the release of histamine and other mediators, thereby, controlling type I hypersensitivity response. The aim of this review paper is to highlight some of the significant molecules designed for the purpose. PMID: 32392111 [PubMed - as supplied by publisher]
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research