The structural basis for inhibition of ribosomal translocation by viomycin [Biochemistry]
Viomycin, an antibiotic that has been used to fight tuberculosis infections, is believed to block the translocation step of protein synthesis by inhibiting ribosomal subunit dissociation and trapping the ribosome in an intermediate state of intersubunit rotation. The mechanism by which viomycin stabilizes this state remains unexplained. To address this,...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Ling Zhang, Ying-Hui Wang, Xing Zhang, Laura Lancaster, Jie Zhou, Harry F. Noller Tags: Biological Sciences Source Type: research