Necrotizing fasciitis in haematological patients: a different scenario

AbstractTo describe and compare the characteristics of necrotizing fasciitis (NF) in patients with and without haematological malignancy. All adult patients diagnosed with NF and treated at our hospital were included (January 2010 –March 2019). Diagnosis was based on intraoperative findings or consistent clinical/radiological characteristics, and patients were classified as group A (with haematological malignancy) or group B (without haematological malignancy). Student’st (quantitative), Fisher ’s exact (qualitative), and Kaplan-Meyer tests were used for the statistical analysis. The study included 29 patients: 8 in group A and 21 in group B. All haematological patients had severe neutropenia (0.2 [0.02–0.5] ×109 cells/L;p <  0.001) and positive blood cultures (100% vs. 61.9%;p = 0.04) at diagnosis. Gram-negative bacilli NF was more common in group A (87.5% vs. 9.5%;p = 0.001), predominantly due toEscherichia coli (50% vs. 9.5%;p = 0.056). Surgical treatment was less common in haematological patients (5 [62.5%] vs. 21 [100%];p = 0.015). Overall, 9 (31%) patients died: 4 (50%) in group A and 5 (23.8%) in group B (p = 0.17). The univariate analysis showed that mortality tended to be higher (OR 3.2; 95%CI 0.57–17.7;p = 0.17) and to occur earlier (2.2 ± 2.6 vs. 14.2 ± 19.9 days;p = 0.13) in haematological patients. The LRINEC index> 6 did not predict mortality in either group. In our study, NF in patients with haematological ma...
Source: Annals of Hematology - Category: Hematology Source Type: research