Statin myopathy pearls

var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); 1. Occurs in fifteen percent of those receiving statins3.  Risk factors for include:        higher dose statin      statin myopathy in a first degree relative      older age      female      small build      concurrent systemic disease (renal, hepatic, or diabetes)      multiple medications including fibrates, nitrates and cyt P450 metabolized drugsgenetic polymorphisms may exist4.  Time course of onset usually one month but may be delayed years5.  Presentation:  weak, high CK, irritability on EMG6.  Co Q depletion may play a role, but studies have not shown CoQ is helpful7.  Immune mediated myopathies can follow withdrawal of statin.8.  fibrates, nitrates and ezetimibe also can cause myopathyvar pageTracker = _gat._getTracker("UA-3639768-12"); pageTracker._initData(); pageTracker._trackPageview();
Source: neurologyminutiae - Category: Neurologists Source Type: blogs