Anti-HIV drugs promote β-amyloid deposition and impair learning and memory in BALB/c mice.

CONCLUSION: Our results suggest that chronic exposure to tenofovir disoproxil fumarate and nevirapine contributes to hippocampal lipid peroxidation and β-amyloid accumulation, respectively, as well as spatial learning and memory deficits in mice even in the absence HIV-infection. These findings further support a possible link between antiretroviral drug toxicity, β-amyloid accumulation and the persistence of HIV associated neurocognitive disorders. PMID: 32378496 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research