Targeting autophagic pathways by plant natural compounds in cancer treatment.

Targeting autophagic pathways by plant natural compounds in cancer treatment. Curr Drug Targets. 2020 May 03;: Authors: Forouzanfar F, Mousavi SH Abstract Nowadays, natural compounds of plant origin with anticancer effect have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve articles related to the study, the databases of Google Scholar, Web of sciences, Medline and Scopus, using the following keywords: Autophagic pathways; herbal medicine, oncogenic autophagic pathways, tumour suppressive autophagic pathways and cancer were searched. Plant natural compounds such as resveratrol, curcumin, oridonin, gossypol and paclitaxel have obvious anticancer potential via autophagic signaling pathways. Although, there is a great need to find new natural compounds and investigate the underlying mechanisms, to facilitate the clinical use of them as potential anti-cancer agents through autophagic induction. PMID: 32364070 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research