Deconstructing the Role of PKC Epsilon in Glucose Homeostasis.

Deconstructing the Role of PKC Epsilon in Glucose Homeostasis. Trends Endocrinol Metab. 2020 May;31(5):344-356 Authors: Schmitz-Peiffer C Abstract The failure of insulin to suppress glucose production by the liver is a key aspect of the insulin resistance seen in type 2 diabetes. Lipid-activated protein kinase C epsilon has long been identified as an important mediator of diet-induced glucose intolerance and hepatic insulin resistance and the current view emphasizes a mechanism involving phosphorylation of the insulin receptor by the kinase to inhibit downstream insulin action. However, the significance of this direct effect in the liver has now been challenged by tissue-specific deletion of PKCĪµ, which demonstrated a more prominent role for the kinase in adipose tissue to promote glucose intolerance. New insights regarding the role of PKCĪµ therefore contribute to the understanding of indirect effects on hepatic glucose metabolism. PMID: 32305097 [PubMed - in process]
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Tags: Trends Endocrinol Metab Source Type: research