Neuronal surface autoantibodies in dementia: a systematic review and meta-analysis

DiscussionIn the first meta-analysis to explore this literature, serum IgG and IgA/IgM NMDAR antibodies were significantly more common in atypical dementias. However, methodological issues and small-sample sizes necessitate caution interpreting this result. Further studies measuring both serum and CSF antibodies are needed to investigate the role of neuronal antibodies in dementia, since evidence of pathogenicity in even a subset of patients could pave the way for novel treatment options.

Source: Journal of Neurology - April 17, 2020 Category: Neurology Source Type: research