The effect of tramadol on blood glucose concentrations: a systematic review.

The effect of tramadol on blood glucose concentrations: a systematic review. Expert Rev Clin Pharmacol. 2020 Apr 15;: Authors: Nakhaee S, Brent J, Hoyte C, Farrokhfall K, Shirazi M, Askari M, Mehrpour O Abstract Introduction: tramadol is a synthetic opioid whose consumption is growing worldwide. In addition to the common side effects of this medication, blood glucose impairment is another important adverse effect. Nevertheless, studies comprehensively summarizing the impact of tramadol use on glucose homeostasis are very sparse. Thus, the present study was performed to collect and summarize the latest information about this issue in a systematic way.Areas covered: An exhaustive literature search was carried out using relevant keywords. Web of Sciences, PubMed, Scopus, and Google scholar were interrogated until 30 June 2019. Case-control, cohort, cross-sectional, clinical trial, case report, and animal studies that focused on the objective of the study were retrieved. Irrelevant studies were excluded after investigating the titles, abstracts, and full text. This review summarizes the results of 761 papers on glycemic changes due to tramadol exposure. Thirty-six publications reported hypoglycemia and 17 hyperglycemia during tramadol use. Twenty-two studies either reported normal blood glucose concentrations, or did not observe any difference in the blood glucose levels following tramadol use. Finally, hypoglycemia was reported in diabe...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Expert Rev Clin Pharmacol Source Type: research