MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1

It has been noted that dysregulation of microRNAs (miRNAs) contributes to the formation of abdominal aortic aneurysm (AAA), a vascular disease associated with progressive aortic dilatation and degradation, and pathological infiltration and activation of inflammatory cells, such as macrophages. Our microarray data revealing that miR-144-5p was the top 1 downregulated miRNA in mouse AAA tissues as compared to normal aortas motivated us to explore its role in AAA development.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research

Related Links:

(University of Maryland School of Medicine) A new landmark study by researchers at the University of Maryland School of Medicine (UMSOM) found that patients with a vascular condition, called abdominal aortic aneurysm, received no benefits from taking a common antibiotic drug to reduce inflammation.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This randomized trial compares the effect of doxycycline with placebo on reducing CT-measured abdominal aortic aneurysms over 2 years among patients with small infrarenal abdominal aortic aneurysms.
Source: JAMA - Category: General Medicine Source Type: research
To identify candidates undergoing elective endovascular aneurysm repair (EVAR) of asymptomatic infrarenal abdominal aortic aneurysm who are eligible for early ( ≤6 hours) hospital discharge or to have EVAR performed in free-standing ambulatory surgery centers.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
In the manuscript, “Palliative care is underutilized and impacts healthcare costs in ruptured abdominal aortic aneurysms,” by Dr Liu et al,1 the authors use administrative data from the Nationwide Inpatient Sample to evaluate the use and costs associated with palliative care consultations in patients presenting w ith ruptured abdominal aortic aneurysms (rAAA). They report that palliative care consultations were only obtained in 14% of patients and were more common among nonoperative patients and those undergoing open repair.
Source: Surgery - Category: Surgery Authors: Source Type: research
This study's purpose is to determine the effect of a previously unassessed measure of quality of care —a hospital's preventable hospitalization rate—on 30-day mortality at both the hospital and individual levels after three major cardiovascular surgery procedures. This is a population-based study using Taiwan's National Health Insurance database. We retrieved data from 2001-2014 for patients who had undergone abdominal aortic aneurysm (AAA) repair, coronary artery bypass graft (CABG), or aortic valve replacement (AVR).
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ADULT – Original Submission Source Type: research
The study by Baderkhan et  al.1 is a retrospective analysis of prospectively recorded data of patients having had endovascular abdominal aortic aneurysm repair (EVAR) between 1998 and 2012 at two Swedish centres. The authors reached two conclusions after analysing the cohorts compliant and not compliant with a post-EVAR su rveillance protocol. The compliant protocol required early post-EVAR computed tomographic angiography (CTA) imaging and annual follow up imaging with CTA and/or duplex ultrasound (DUS).
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Tags: Invited Commentary Source Type: research
We present a case of ruptured abdominal aortic aneurysm with an aortocaval fistula that was successfully treated with percutaneous endovascular aneurysm repair under local anaesthesia. Despite a persistent type 2 endoleak the aneurysm sack shrank from 8.4cm to 4.8cm in 12 months. The presence of an aortocaval fistula may have depressurised the aneurysm, resulting in less bleeding retroperitoneally and may have promoted rapid shrinkage of the sac despite the presence of a persistent type 2 endoleak. PMID: 32436721 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
Any provider who has cared for patients with abdominal aortic aneurysms (AAA) knows that treating a patient with a ruptured AAA is completely different from treating a patient electively for AAA. Regardless of whether the treatment strategy is open or endovascular, all would agree that improved identification of AAA before rupture, enabling elective repair, results in markedly improved patient outcomes. As a result, AAA screening is critically important and has been implemented for specific populations in the United States and around the globe.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Invited commentary Source Type: research
A ruptured abdominal aortic aneurysm (rAAA) remains one of the most challenging, morbid, and mortal conditions that confronts a vascular surgeon. A number of patient-, surgeon-, and systems-based factors determine whether the optimal approach to care for these challenging patients is endovascular aneurysm repair (EVAR) or open surgical repair (OSR). In this issue of the Journal, Salata et  al1 compare the short- and long-term results of EVAR and OSR for rAAA in Ontario between 2003 and 2016. They demonstrate that EVAR is associated with significant benefit in 30-day mortality and a reduction in major adverse cardiac events.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Invited commentary Source Type: research
Repair of ruptured infrarenal abdominal aortic aneurysms (rAAA) has shifted from open surgical (OAR) to endovascular (EVAR) over the last decade. However, the long term impact of EVAR vs. OAR for rAAA has not been well described.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Selected Abstracts from the May Issue of the European Journal of Vascular and Endovascular Surgery Source Type: research
More News: Abdominal Aortic Aneurysm | Aortic Aneurysm | Cardiology | Cytology | Heart