Molecules, Vol. 25, Pages 1725: A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma

Conclusion: Local delivery of iRed could augment the in vivo gene silencing effect without eliciting pronounced innate immune stimulation. Our results might hold promise for widespread utilization of iRed as an RNAi-based therapeutic for intracelial malignant cancers.

Source: Molecules - April 8, 2020 Category: Chemistry Authors: Hidenori Ando Noriko Saito-Tarashima Amr S. Abu Lila Nozomi Kinjo Taro Shimizu Yu Ishima Noriaki Minakawa Tatsuhiro Ishida Tags: Article Source Type: research