Development of an ultrasound triggered Nanomedicine-microbubble complex for chemo-photodynamic-gene therapy

Publication date: Available online 8 April 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Yongho Jang, Doyeon Kim, Hohyeon Lee, Hyejin Jang, Suhyeon Park, Ga Eul Kim, Hak Jong Lee, Hyun Jung Kim, Hyuncheol Kim
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research

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Transfection of TGF-β shRNA by using ultrasound-targeted microbubble destruction to inhibit the early adhesion repair of rats wounded Achilles tendon in vitro and in vivo. Curr Gene Ther. 2020 May 16;: Authors: Huang S, Xi X, Qiu L, Wang L, Zhu B, Guo R, Tang X Abstract BACKGROUND: Tendon injury is a major orthopedic disorder. Ultrasound-targeted microbubble destruction (UTMD) provides a promising method for gene transfection, which can be used for the treatment of injured tendons. OBJECTIVE: The purpose of this study was to investigate the optimal transforming growth factor beta (TGF-β...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research
Conclusions: Further development of the PCI microneedle is warranted especially for AAV corneal gene therapy and offers the potential to enhance transduction while significantly reducing safety concerns and intraclinician and interclinician injection variability.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
This study consisted of three parts: (1) in vitro experiments to establish the 'proof of principal' that combination of RFH and HSV-TK gene therapy has the synergistic effect on human ovarian cancer cells; (2) creation of bioluminescence imaging-detectable rat ovarian cancer model; and (3) in vivo experiments using this rat model to validate the technical feasibility of the combination therapy. Cells and nude rats were divided into four groups: (i) combination therapy (HSV-TK/GCV + RFH); (ii) RFH; (iii) HSV-TK/GCV; and (iv) phosphate-buffered saline (PBS). Data were analyzed using Dunnett t-test or ...
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00983
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
Advanced pulsed focused ultrasound “preconditioning” schemes for amplifying the dispersion and efficacy of non‐viral brain‐penetrating nanoparticle formulations that are delivered across the blood–brain barrier are described. The powerful focused ultrasound preconditioning strategy presented here may be appended to already‐ established protocols to markedly augment the efficacy of nonviral gene therapy strategies in the central nervous system. AbstractMicrobubble activation with focused ultrasound (FUS) facilitates the noninvasive and spatially ‐targeted delivery of systemically administered thera...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research
Cancer Gene Therapy, Published online: 30 October 2019; doi:10.1038/s41417-019-0148-0Retraction Note: Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
The PIK3 CA gene encodes the p110 α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC). There are currently ongoing therapies against tumors based on PIK3 CA inhibition. Because microRNAs (miRNAs) play an important role in post-transcriptional reg ulation and are also involved in the inhibition of PIK3 CA expression to suppress cancer cell proliferation, overexpression of tumor-suppressive miRNA is a promising therapeutic approach for HCC therapy.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
Advanced pulsed focused ultrasound “preconditioning” schemes for amplifying the dispersion and efficacy of non‐viral brain‐penetrating nanoparticle formulations that are delivered across the blood–brain barrier are described. The powerful focused ultrasound preconditioning strategy presented here may be appended to already‐ established protocols to markedly augment the efficacy of nonviral gene therapy strategies in the central nervous system. AbstractMicrobubble activation with focused ultrasound (FUS) facilitates the noninvasive and spatially ‐targeted delivery of systemically administered thera...
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone. Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/ Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we used immunoassays, transmission electron microscopy and cardiac ultrasound to confirm that p27 haploinsufficiency prevents myocardial apoptosis by restoring autophagy protein 5‑mediated autophagy flux in the early stages of MI. The present study provides a novel method for studying MI or ischemic heart disease therapy. PMID: 31485654 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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