Novel method for reduction of virus load in blood plasma by sonication
ConclusionsBuilding upon the information gained, an optimum inactivation can be reached via raising of power density up to 1200 W and simultaneous lowering of frequency down to 27 kHz. In addition, the combination of the two physical methods UV treatment and ultrasound may yield optimum results without the need of substance removal after the procedure.
Publication date: Available online 3 June 2020Source: Life SciencesAuthor(s): Na Fu, Huijuan Du, Dongdong Li, Yu Lu, Wencong Li, Yang Wang, Lingbo Kong, Jinghua Du, Suxian Zhao, Weiguang Ren, Fang Han, Rongqi Wang, Yuguo Zhang, Yuemin Nan
Authors: Jiao J, Droste R, Drukker L, Papageorghiou AT, Noble JA Abstract Recent advances in deep learning have achieved promising performance for medical image analysis, while in most cases ground-truth annotations from human experts are necessary to train the deep model. In practice, such annotations are expensive to collect and can be scarce for medical imaging applications. Therefore, there is significant interest in learning representations from unlabelled raw data. In this paper, we propose a self-supervised learning approach to learn meaningful and transferable representations from medical imaging video with...
Authors: Droste R, Chatelain P, Drukker L, Sharma H, Papageorghiou AT, Noble JA Abstract Anatomical landmarks are a crucial prerequisite for many medical imaging tasks. Usually, the set of landmarks for a given task is predefined by experts. The landmark locations for a given image are then annotated manually or via machine learning methods trained on manual annotations. In this paper, in contrast, we present a method to automatically discover and localize anatomical landmarks in medical images. Specifically, we consider landmarks that attract the visual attention of humans, which we term visually salient landmarks...
AbstractTORCH, as coined by Nahmias et al. consists of Toxoplasmosis, other infections (includes, syphilis, HIV, Hepatitis viruses, varicella virus and Parvovirus B19), Rubella, Cytomegalovirus (CMV) and Herpes simplex virus. These infections are transmitted prenatally, perinatally, and postnatally through transplacental passage, contact with blood and vaginal secretions or from exposure to breast milk for CMV, HIV and HSV and infection generally manifests at birth, in infancy or in later years of life. The disease burden is maximum in low to middle-income countries. As treatment and prevention strategies are available for...
CONCLUSION: Monitoring the titer of IVIG lots and seroprevalence of donor populations is important for anticipating future changes in virus antibody titers of IVIG lots and can provide useful information of clinical interest. PMID: 30284288 [PubMed - as supplied by publisher]
ConclusionsWhilst various pathological processes have been implicated in the development of indeterminate hepatitis, the specific cause remains elusive. There is an urgent need for general consensus on a specific definition and exclusion of confounding aetiologies with coordinated multicentre investigation of this rare condition to identify aetiology and develop therapies to reduce the significant mortality and need for emergency liver transplantation associated with this condition.
CONCLUSION: Ultrasonographic findings associated with fetal infection are neither sensitive nor specific. Testing for STORCH infections should take into account exposure history, clinical signs and symptoms, obstetric history, and fetal ultrasound findings, but with special attention paid to cytomegalovirus and parvovirus B19. PMID: 29185251 [PubMed - in process]
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CONCLUSION The phenotype of the microcephaly cases associated with the current outbreak at Rio Grande do Norte state is more severe and different from previous cases. The data here presented can be used as a guideline for those who want to differentiate microcephalies caused by the probable ZIKV-associated outbreak. The consequences of this type of microcephalies to the children, their families and the public health system are still to be determined. COMPETING INTERESTS The authors declare having no competing interests. DATA AVAILABILITY STATEMENT The data presented in this article is freely available from FigShare.
CONCLUSIONS Further research is required to clarify whether certain infections do increase miscarriage risk and whether screening of newly pregnant women for treatable infections would improve reproductive outcomes.