Adverse Outcomes Associated with Inpatient Administration of Beers List Medications Following Total Knee Replacement.

Adverse Outcomes Associated with Inpatient Administration of Beers List Medications Following Total Knee Replacement.
Clin Ther. 2020 Apr 03;:
Authors: Anderson BJ, Liu M, Cui X, Stevens M, Arensman MA
Abstract
PURPOSE: Beers List drugs are potentially harmful in older adults and are grouped by level of risk. Over 9000 total knee arthroplasties (TKAs) are performed each year Veterans Affairs (VA) hospitals, primarily on older adults. Minimal data on the administration of Beers List drugs following arthroplasty currently exists in the literature. Our goal was to quantify the risks of these drugs following TKA. We hypothesized that increasing doses of Beers List drugs would be associated with increased risks for readmission, reoperation, emergency department (ED) visits, and mortality.
METHODS: In this retrospective cohort study, data from TKAs performed in VA hospitals from 2010 to 2014 were examined, with complicated or bilateral procedures excluded. The data were obtained from the VA Corporate Data Warehouse. The outcomes examined were readmission, postoperative ED visits, reoperation on ipsilateral knee, and mortality. Beers List drugs were divided into 3 categories: medications to use with caution (Beers 0); medications to avoid in older adults (Beers 1); and medications to avoid in certain disease states (Beers 2). Beers 2 was not included in the final analysis due to an inability to verify appropriate diagnostic criteri...

Source: Clinical Therapeutics - April 2, 2020 Category: Drugs & Pharmacology Authors: Anderson BJ, Liu M, Cui X, Stevens M, Arensman MA Tags: Clin Ther Source Type: research