Repeated anaphylaxis to cefuroxime in teenager and cross-reactivity to cephalosporins due to R2 side chain

Cephalosporins are one of the most prescribed classes of antibiotics1 and 1-3% of population report a cephalosporin allergy2. They are beta-lactam antibiotics and their chemistry, mechanism of action and toxicity are similar to penicillins. The most common classification of cephalosporins is by generation. There are five generations of cephalosporins.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research

Related Links:

We have read with interest the report by Dribin et al investigating the association between history of asthma and anaphylaxis severity in children 1. The authors concluded that children hospitalized for anaphylaxis with a past medical history of asthma were not more likely to have severe anaphylactic reactions compared with children without asthma. However, we noticed that asthma control status at the time of anaphylaxis was not determined in the study. As mentioned by the authors, a position paper from the European Academy of Allergy and Clinical Immunology identifies asthma as a risk factor for fatal anaphylaxis, but it ...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Letters to the Editor Source Type: research
CONCLUSIONS: Selective EP2 agonism is a powerful pharmacological strategy to prevent MCs from being activated through IgE-mediated mechanisms and from causing deleterious effects. The MC EP2 receptor may be an effective pharmacological target in allergic and other MC-mediated conditions. PMID: 32400135 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
CONCLUSIONS: Lcr35 treatment during OIT had some synergic effect for protection against anaphylaxis in a mice model of egg allergy. These findings should be confirmed in future animal studies including more detailed immunological profiles and human studies. PMID: 32400134 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
ConclusionA multidisciplinary approach to the treatment of sinonasal symptoms using both escalation of medical therapy and surgical approaches may improve QOL of patients with suspected MCAS. Consensus criteria for MCAS, which includes elevation in tryptase over baseline during an episode, may exclude the full spectrum of individuals with MCAS from potentially beneficial treatment.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionOur data confirm the lack of consensus regarding the number of AAIs to prescribe. Despite the European Medical Agency recommendation, the majority of allergy experts prescribed one autoinjector per patient. However, under distinct circumstances (e.g. mastocytosis, asthma, excess body weight, a history of severe anaphylaxis, or restricted access to immediate emergency), experts tended to prescribe more AAIs, which is in accordance with the European Academy of Allergy and Clinical Immunology guidelines.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Purpose of review To present an update on the recent advances in the understanding of the mechanisms and practical management of oral mite anaphylaxis (OMA, pancake syndrome). Recent findings Among novel observations regarding OMA, this review highlights the increased prevalence of aspirin/NSAID hypersensitivity inpatients affected by OMA, the association of OMA with exercise-induced anaphylaxis, the presentation of OMA simulating acute asthma, the occurrence of OMA in childhood, the high severity and lethal potential of OMA, the contamination of other foods, such as oat and corn flour with mites, and the simultaneous...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research
Conditions:   Asthma in Children;   Allergy Intervention:   Device: Advanced multimodal wireless vital signs monitor Sponsors:   Northwestern University;   Ann&Robert H Lurie Children's Hospital of Chicago Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
When a child presents to the emergency department (ED) with anaphylaxis the first priority is immediate stabilization. Shortly thereafter, though, the clinician must decide whether a prolonged period of monitoring, including hospitalization, is warranted. And although concomitant asthma is a recognized risk factor for severe anaphylaxis (Allergy 2014;69:1026-45), it may not be a strong predictor (Allergy 2016;71:1241-55) and little is certain as to whether a co-existing diagnosis of asthma should, in and of itself, enter into that decision to admit.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
AbstractPurpose of ReviewIt is rare to see pediatric patients with previous perioperative anaphylaxis receiving future anesthesia, but it is critical to understand how to choose assessments, interpret the results, and develop a future anesthetic plan.Recent FindingsAnalysis of the results revealed that patients, at any age, regardless of sex and  nationality, and the number of surgeries, have the risk of perioperative anaphylaxis while the risk of allergy increases as patients present multiple surgical events or have a previous history of atopy. 94.7% of pediatric patients with allergy testing after perioperative anap...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
AbstractBackgroundPollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previous direct comparative studies investigating quality of life (QoL) of all three immunotherapy regimes. The aim of this study was to compare QoL and safety in children receiving these immunotherapies for AR.MethodsDemographic characteristics, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Visual Analogue (VAS) scores were assessed in 249 children undergoing HDM and pollen immunotherapy at ...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
More News: Allergy | Allergy & Immunology | Anaphylactic Shock | Asthma | Cefuroxime | Chemistry | Toxicology