Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.

Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines. Int J Oncol. 2020 Apr 01;: Authors: Mirzapoiazova T, Pozhitkov A, Nam A, Mambetsariev I, Nelson MS, Tan YC, Zhang K, Raz D, Singhal S, Nasser MW, Kulkarni P, Batra SK, Sattler M, Salgia R Abstract The post‑translational modification of proteins by ubiquitinating enzymes plays a central role in a number of cellular functions, such as cell proteolysis, DNA repair, and cell signaling and communication. Deubiquitinating enzymes (DUBs) disassemble ubiquitin chains and remove ubiquitin moieties from proteins. Targeting DUBs in cancer models has revealed an important role for these enzymes in tumorigenesis, and they therefore have emerged as attractive therapeutic targets. In the present study, the effects of three DUB inhibitors, PR‑619, RA‑9 and LDN‑91946, on a non‑small cell lung cancer cell line (A549) and a mesothelioma cell line (H2373) were investigated. PR‑619 significantly inhibited cell adhesion and the proliferation of both cell lines. RA‑9 exerted an inhibitory effect on the adhesion and proliferation of H2373 cells, whereas it had no effect on A549 cells. Notably, however, while PR‑619 attenuated the proliferation of both cell lines, it exerted an opposite effect on cell motility; in the case of A549 cells, there was a significant increase in cell motility, while for the H2373 cells, there was a signif...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research

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Residents in privatized housing on nearly 50 Army installations cited concerns with issues such as lead paint and asbestos, the toxic building material linked to mesothelioma cancer, according to a recent report from the Department of the Army Inspector General. The report, which was made public earlier this month, includes surveys, document reviews and interviews with residents at 49 Army installations across the U.S., including Fort Bragg (N.C.), Fort Campbell (Ky.) and Fort Hood in Texas. Military families at 48 of the 49 sites cited concerns with safety or environmental issues inside the aging on-base housing at the ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
A research team from the Duke University Medical Center and the Massachusetts Institute of Technology has uncovered a new compound with potential to make chemotherapy more effective in treating various cancers. The small-molecule inhibitor drug — JH-RE-06 — showed an ability to better-sensitize tumors to Cisplatin, the popular chemotherapy drug most often used for mesothelioma cancer patients. When combined with Cisplatin, the drug also showed an ability to prevent those tumor cells from becoming treatment resistant, a common problem with this rare cancer caused by asbestos exposure. The research was done on l...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Joe Abdo1, Christopher S. Wichman2, Nicholas E. Dietz1,3, Pawel Ciborowski4, John Fleegel1, Sumeet K. Mittal1,5 and Devendra K. Agrawal1* 1Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, United States 2Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States 3Department of Pathology, CHI Health Creighton University Medical Center, College of Medicine, Omaha, NE, United States 4Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE, United States 5Norton Thoracic Institute, St....
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Two Canadian government agencies are sponsoring legislation that will prohibit the import, use and sale of asbestos and products containing the cancer-causing mineral. The proposed Prohibition of Asbestos and Asbestos Products Regulations, sponsored by Environment and Climate Change Canada and Health Canada, comes more than a year after the Canadian government promised a comprehensive ban on asbestos by 2018. Additional amendments to the existing Export of Substances on the Export Control List Regulations (ESECLR) would restrict the export of all forms of asbestos, going beyond Canada’s commitment under the Rotterdam...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: asbestos ban in canada Catherine McKenna Environment and Climate Change Canada Export of Substances on the Export Control List Regulations Health Canada Jesse Todd Kathleen Ruff Prohibition of Asbestos and Asbestos Products Regulations Rig Source Type: news
The brutal winter storms affecting most of the U.S. bring more dangers than just freezing temperatures and icy roads. Snow, freezing rain and weather forecasts in the single digits can also affect building materials containing deadly asbestos. For example, a Massachusetts elementary school remains closed after a pipe burst over the holiday break and damaged asbestos ceiling tiles. Fitchburg Public Schools Superintendent Andre Ravenelle said Crocker Elementary School will be closed until at least Friday as the building undergoes remedial work. “We are working with the appropriate agencies and licensed experts to remed...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Andre Ravenelle asbestos in schools Crocker Elementary School environmental protection agency Fitchburg High School Longsjo Middle School Massachusetts School Building Authority Reingold Elementary School Sally Cragin winter storms Source Type: news
We examined the development of knowledge concerning the risks posed by asbestos to seamen working aboard merchant ships at sea (i.e. commercial, rather than naval vessels). Seamen were potentially exposed to "in-place" asbestos on merchant ships by performing intermittent repair and maintenance tasks. We reviewed studies measuring airborne asbestos onboard merchant ships and health outcomes of merchant seamen, as well as studies, communications, and actions of U.S. organizations with roles in maritime health and safety. Up to the 1970s, most knowledge of the health risks of asbestos was derived from studies of wo...
Source: Inhalation Toxicology - Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research
This study is part of a broad development program that includes a number of additional planned studies." TRACON Pharmaceuticals develops novel targeted cancer therapies. Its TRC105 antibody is directed at renal cell carcinoma and hepatocellular carcinoma. This clinical trial with TRC102 is one of five nationally involving methoxyamine, but one of more than 200 trials for mesothelioma.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Research & Clinical Trials Source Type: news
Background: ATR mediates the homologous recombination DNA repair pathway and cellular response to replication stress. VX-970 is a potent and selective inhibitor of ATR (Ki
Source: Molecular Cancer Therapeutics - Category: Cancer & Oncology Authors: Tags: Clinical Trials: Oral Presentations - Proffered Abstracts Source Type: research
Conclusion - the need for a global health approach Asbestos and ARD have emerged as global health issues. All countries with a history of asbestos use are experiencing an epidemic of ARD, with the stage of the epidemic being a function of the country’s past asbestos use, whether and when it implemented a ban, and, if no ban is in place, at what levels it continues to use the material. Gaps in human capital and technology available to countries warrant international cooperation. The expansion of national bans in industrializing countries and reducing the burden of ARD in industrialized countries are the short-term targets...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Commentary Source Type: research
Simple aspirin could be the key to preventing or delaying the growth of malignant mesothelioma for those who spent years working in high-risk occupations, a new report shows. Researchers at the University of Hawaii Cancer Center concluded the popular over-the-counter medication can inhibit the growth of mesothelioma tumor cells by blocking the inflammatory effects of a particular molecule that plays a critical role in the progression of the disease. Although the study used lab mice, its relevance already has reached the clinical stage. "The findings were very convincing. The aspirin worked really well...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news
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