The role of leptin and obesity on male infertility

Purpose of review Several studies suggest a strong association between leptin, obesity, and infertility with respect to the hypothalamic–pituitary–gonadal (HPG) axis, androgen regulation, and sperm production, but the direct mechanistic association between these is still largely unexplored. This review focuses on understanding the association between leptin, obesity, and male infertility. Recent findings Obesity is linked to fertility dysfunction in both genders. Obesity in men may affect their fertility by impaired spermatogenesis, reduced testosterone levels, erectile dysfunction, and poor libido by putatively targeting the HPG and hypothalamic–pituitary–adrenal axes. Leptin plays key roles in many metabolic functions, including reproduction. High concentrations of leptin have been found in infertile men with disorders affecting the testicular parenchyma, including nonobstructive azoospermia, oligozoospermia, and oligo-astheno-teratozoospermia. Additionally, serum leptin levels have negative associations with serum testosterone levels and sperm parameters and positive associations with serum follicle-stimulating hormone and luteinizing hormone levels and abnormal sperm morphology. Summary Excessive leptin production may be a significant contributor to the development of androgen insufficiency and reduced reproductive function in obese men. Understanding the relation between leptin, obesity, and reproduction may shed light on future targeted t...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research

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Authors: Watahiki T, Okada K, Warabi E, Nagaoka T, Suzuki H, Ishige K, Yanagawa T, Takahashi S, Mizokami Y, Tokushige K, Ariizumi SI, Yamamoto M, Shoda J Abstract Gender and menopause influence the severity and development manner of nonalcoholic steatohepatitis (NASH). Male p62/Sqstm1 and nuclear factor E2-related factor-2 (p62 and Nrf2) double-knockout (DKO) mice exhibit severe steatohepatitis caused by hyperphagia-induced obesity, overload of lipopolysaccharide (LPS) into the liver, and potentiation of the inflammatory response in Kupffer cells. However, the pathogenetic phenotype of steatohepatitis in female DKO...
Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
Conclusion: The prevalence of self-reported hypertension increased significantly in the study period. Considering this disease ’ s impact on society, knowing its current prevalence and identifying its main associated factors, the need to intensify the efforts to prevent it disease is evident in order to mitigate damage to individuals and impact on public expenditure.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Conclusion: Worst indicators among women receiving BF reflect social inequalities inherent in this most vulnerable group. The study also shows that BF is being targeted at the most vulnerabl e women.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
CONCLUSION: The matrix effect caused by exogenous and endogenous interferences in the blood could be a hidden factor increasing the prevalence of vitamin D deficiency by causing falsely low 25OHD3 values. Suspicious results should be remeasured by a dilution study. PMID: 32496995 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Publication date: Available online 5 June 2020Source: Respiratory Physiology &NeurobiologyAuthor(s): Bryce N. Balmain, Daniel P. Wilhite, Dharini M. Bhammar, Tony G. Babb
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Publication date: Available online 5 June 2020Source: Heart &LungAuthor(s): Zyad T. Saleh, Terry A. Lennie, Muhammad Darawad, Hamza Alduraidi, Rami A. Elshatarat, Issa M. Almansour, Debra K. Moser
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
CONCLUSION: Class III obesity, comorbidities, and older age are associated with a longer diagnosis-to-surgery time. As the prevalence of obesity and endometrial cancer rise, processes are needed to promote equitable, timely access to care. PMID: 32487508 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Conclusions: The contribution of UPF was expressive in the feeding of the students and it was positively associated with the excess of wei ght and with the habit of eating while watching television. These findings indicate the importance of nutritional interventions to promote healthy habits, thus preventing overweight during childhood.RESUMO Objetivo: Avaliar a contribui ção dos alimentos ultraprocessados (AUP) na dieta de escolares e seus fatores associados. Métodos: Estudo transversal realizado com crianças entre oito e 12 anos de idade em escolas públicas de uma capital brasileira. Fo...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
Condition:   Infertility, Female Intervention:   Behavioral: Mindfulness based psychological intervention Sponsor:   University Hospital, Geneva Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Childhood Obesity;   Physical Activity;   Sedentary Lifestyle;   Body Fat Intervention:   Other: active video-games Sponsor:   Universidad de Zaragoza Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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