Early Experience in Correlation of Donor Derived, Cell Free DNA Testing with Intravascular Ultrasound Evidence and Overt Coronary Artery Vasculopathy

Coronary artery vasculopathy (CAV) remains a significant limitation for long-term survival after heart transplantation (HT), observed in 30-45% of recipients by 5 years and 50-65% by 10 years post-HT. Despite the increased fidelity, the detection of CAV at the level of the vessel remains invasive and with various modalities used in CAV screening, the ability to detect sub-occlusive disease or disease in vessels less than 1.5 mm diameter remains problematic. Donor ‐derived, cell‐free DNA (dd‐cfDNA (AlloSure)), detected in recipient blood, has been established as a non-invasive marker of allograft injury, useful in the assessment of organ rejection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (609) Source Type: research