New perspectives on the insulin therapy

AbstractInsulin was discovered by Banting and Best in 1921, and was subsequently applied for the treatment of diabetes. Porcine or bovine insulin purified from their pancreas had been used clinically for more than 50 years until the development of the methods to produce recombinant human insulin by genetical engineering techniques. The Diabetes Control and Complications Trial (DCCT) (1) and our Kumamoto Study (2) provided the evidences that better glycemic control could be obtained by intensive insulin therapy consisted of the supplementation of both basal and postprandial insulin, which in turn resulted in the prevention of the initiation and progression of diabetic microvascular complications.

Source: Journal of Diabetes Investigation - March 31, 2020 Category: Endocrinology Authors: Eiichi Araki, Hirotaka Araki, Takafumi Senokuchi, Hiroyuki Motoshima Tags: UPDATES Source Type: research