76. Histrelin Implants for Puberty Suppression in Transgender Children and Adolescents

Transgender children and adolescents may present to care for puberty suppression to prevent undesired and potentially irreversible phenotypic changes that are incongruent with their gender identity. Though histrelin implants have been approved and studied for hormonal axis suppression in medical conditions such as prostate cancer and central precocious puberty, limited data describe its use among children and adolescents with gender dysphoria. Our study aims to characterize the use of the histrelin implant for puberty suppression among transgender youth.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research

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Prostate cancer incidence in older adolescents and young adult men has increased in most countries for unknown reasons.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Five nursing and midwifery specialists were inducted as scholars at this year’s prestigious Mary Seacole awards today (Thursday 24 October) at a ceremony at St Thomas’ Hospital in London. UNISON co-sponsors the awards, which offer an opportunity for healthcare workers to undertake a project, educational or development activity that benefits and improves the health of people from BME communities. Recipients have been working on their projects for the past year, funded by Health Education England, and today is the culmination of all their hard work. The awards are in memory of Mary Seacole, the Jamaican Scottish ...
Source: UNISON Health care news - Category: UK Health Authors: Tags: News Press release nursing Source Type: news
The prostates of older mice contain more luminal progenitor cells — cells capable of generating new prostate tissue — than the prostates of younger mice, UCLA researchers have discovered.The observation,published in  Cell Reports, helps explain why, as people age, the prostate tends to grow, leading to an increased risk for prostate cancer and other conditions.“Understanding what’s causing the prostate to grow with age helps us to consider strategies to prevent the expansion of these cells and possibly reduce a person’s risk for prostate growth or disease,” said Andrew Goldstein, me...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
SummaryOsteosarcoma (OS) is the most common primary malignant bone tumor and mainly affects children and adolescents. The OS five-year survival rate remains very low. Thus, novel therapeutic protocols for the treatment of OS are needed. Several approaches targeting deregulated signaling pathways have been proposed. The antitumoral effects of polyphenols, which are naturally occurring compounds with potent antioxidant and anti-inflammatory activity, have been investigated in different tumors. Gossypol, which is a natural polyphenolic aldehyde isolated from the seeds of the cotton plant, has been shown to exert antitumoral a...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Hedi Zhao1, Vanessa Moarbes1, Véronique Gaudreault1, Jichuan Shan1, Haya Aldossary1, Louis Cyr2 and Elizabeth D. Fixman1* 1Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montréal, QC, Canada 2Research Institute of the McGill University Health Centre, Montréal, QC, Canada Sex differences in asthma prevalence are well-documented but poorly understood. Murine models have contributed to our understanding of mechanisms that could regulate this sex disparity, though the majority of these studies have examined responses present after Th2 adaptive immunity ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In conclusion, our results of bioinformatic analysis, in vitro and in vivo functional analysis suggested that REST may serve as a promoter of metastasis in pancreatic cancer. Introduction Pancreatic cancer, ranked fourth in cancer-related mortality, is characterized by its rapid progression and early metastasis (1). Patients are hardly cured by surgical resection due to the existing local invasion and distant metastasis (2). Elevating the overall survival rate for pancreatic cancer requires further elucidation of the underlying molecular mechanism of its metastasis. Epithelial-mesenchymal transition (EMT), especially...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion In conclusion, neither the bottom-up nor top-down strategy should be used in isolation. While utilizing the bottom-up approach researchers are likely to see effects rather quickly, but these effects will likely be limited to small pockets of populations, and potentially not very long lasting. Utilizing the top-down approach is likely to yield much larger dividends, but it also comes with a much longer time commitment, and no guarantee of success after years of advocacy work. To maximize return-on-investment, breast cancer prevention researchers should seek to translate their findings simultaneously along both o...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the ex...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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