Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Antimicrob Agents Chemother. 2020 Mar 23;:
Authors: Ekins S, Madrid PB
Abstract
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola Virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
PMID: 32205350 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Ekins S, Madrid PB Tags: Antimicrob Agents Chemother Source Type: research
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