The Lancet Infectious Diseases: Singapore modelling study estimates impact of physical distancing on reducing spread of COVID-19
(The Lancet) A new modelling study conducted in a simulated Singapore setting has estimated that a combined approach of physical distancing  interventions, comprising quarantine (for infected individuals and their families), school closure, and workplace distancing, is most effective at reducing the number of SARS-CoV-2 cases compared with other intervention scenarios included in the study.
Athletes who test positive for SARS-CoV-2, the virus that causes COVID-19, should take at least two weeks off from intense or competitive exercise and even more if they show signs of myocarditis, according to two new reports.Reuters Health Information
Infants with symptomatic COVID-19 infection harbor higher SARS-CoV-2 viral loads in the nose at presentation but develop less severe disease as compared to older children and adolescents, report clinicians from New York City.Reuters Health Information
Authors: Doggrell SA Abstract INTRODUCTION: Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe Covid-19. AREAS COVERED: This evaluation is of LOTUS China (the Lopinavir Trial for Suppression of SARS-Cov-2 in China), which was a randomised trial in hospitalised subjects with Covid-9 in a respiratory sample and pneumonia. As, in severe Covid-19, lopinavir/ritonavir had no beneficial effects but increased gastrointestinal adverse effects, this combination should not be used at this stage of Covid-19. EXPERT OPINION: In my opi...
Clinicians in Italy report two cases of possible vertical transmission of SARS-CoV-2, the virus responsible for COVID-19, from the mother to the baby in utero.Reuters Health Information
Healthcare workers don't often contract COVID-19 from patients known to be infected with the SARS-CoV-2 virus, and their presentation is often milder than those of other patients, according to reports from China and the Netherlands.Reuters Health Information
Our “hidden enemy,” in plain sight.
Mast cells are present in mucosal and connective tissues throughout the body. They participate in the innate and adaptive immune process and have an important role in inflammation and allergy. Mast cells located in the submucosa of the respiratory tract are known to be activated by the SARS-CoV-2 virus.
Conditions: COVID-19; Sars-CoV2 Interventions: Drug: Sargramostim; Drug: Standard of care Sponsor: Partner Therapeutics, Inc. Not yet recruiting
Condition: Sars-CoV2 Intervention: Drug: Octagam Sponsors: George Sakoulas, MD; Octapharma Recruiting
Conditions: Severe Acute Respiratory Syndrome; COVID Intervention: Drug: SARS-CoV-2 plasma Sponsor: Ascension South East Michigan Recruiting