Pharmacokinetics after Periocular Methylprednisolone Sodium Succinate Injection in Rabbit Eyes.

Pharmacokinetics after Periocular Methylprednisolone Sodium Succinate Injection in Rabbit Eyes. Evid Based Complement Alternat Med. 2020;2020:8120398 Authors: Lu HY, Wang RQ, Li X, Li X Abstract The present study aimed to determine the pharmacokinetics and distribution of methylprednisolone sodium succinate (MPSS) and its metabolic product methylprednisolone (MP) in plasma and ocular tissues after periocular injection of MPSS in rabbit eyes. Forty-eight healthy New Zealand white rabbits were randomly divided into 12 groups, including the control group and 11 MPSS-treated groups sampling at different time points. Rabbits in the MPSS-treated groups underwent left eye periocular injection of MPSS (10 mg). The pharmacokinetics of MPSS and MP in plasma and ocular tissues (including aqueous humor, vitreous, iris, lens, sclera, optic nerve, and choroid and retina) were investigated by liquid chromatography tandem mass spectrometry (LC-MS/MS). After periocular injection, the time of maximum concentration (T max) of MPSS ranged from 0.25 h to 1 h in ocular tissues and was 0.25 h in plasma. T max of MP in ocular tissues ranged from 0.5 h to 6 h, and T max of MP in plasma was 0.5 h. The maximum concentration (C max) of MPSS and MP and the area under the curve (AUC0-t ) in ocular tissues from high to low was sclera, optic nerve, choroid and retina, iris, and lens. Especially, the concentrations of MPSS and MP in the lens were much ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research