Impact of gender on immature platelet count and its relationship with coronary artery disease

AbstractThe impact of platelet parameters on the cardiovascular risk is still debated. Gender differences in platelet volume indexes and turnover have been previously reported, potentially conditioning their role in the development of coronary artery disease (CAD). However, few studies have addressed, so far, the impact of gender on the immature platelet fraction (IPF) and count (IPC) and their relationship with CAD. We enrolled consecutive patients undergoing coronary angiography in a single centre. IPF and platelet indexes were measured at admission. Significant CAD was defined as the presence of at least one coronary stenosis more than 50%. A total of 2550 patients were included, 1835 (72%) were males, and 715 (28%) were females. Female patients were older (p  <  0.001), with lower BMI (p = 0.002), lower prevalence of active smoking (p <  0.001), previous MI, previous PCI and CABG (p = 0.001, p = 0.001, p <  0.001), whilst a higher prevalence of renal failure (p = 0.02), acute presentation (p <  0.001) and CAD (p <  0.001). Platelet count was higher in females (p <  0.001), as well as the IPC levels (838.38 ± 562.05 vs 792.24 ± 535.66, p = 0.05) with no difference in the levels of immature platelet fraction (3.67 ± 2.68% vs 3.74 ± 2.6%, p = 0.55) or the prevalence of patients with IPF ≥ 3rd tertile (33.7% vs 35.2%, p = 0 .26). At multivariate analysis, after correction for basel...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research