Lower gray matter volumes of frontal lobes and insula in adolescents with anorexia nervosa restricting type: Findings from a Brain Morphometry Study.

CONCLUSIONS.: The topographic distribution of GM reduction in a homogenous group of AN-r involves regions responsible for the emotional and cognitive deficits associated with the illness. These findings are discussed in relation to the roles of the insular cortex and the frontal lobes. PMID: 32172703 [PubMed - in process]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research

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ConclusionAnorexia nervosa is an eating disorder with a strong genetic component that contributes to its etiology. Various genetic approaches might help in the molecular diagnosis of this disease and in devising novel therapeutic options.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: REVIEW ARTICLE Source Type: research
Hypothalamic amenorrhea is common in adolescents and young adults (AYAs) with anorexia nervosa (AN), and ovarian reserve is not routinely assessed as part of routine clinical care. Multiple neuroendocrine alterations occur with AN, and appear to impair reproductive health. AN leads to higher rates of fertility problems, later age at childbearing, and increased rates of obstetrical complications. How or when AN negatively influences future fertility is unclear. We sought to determine whether biomarkers of ovarian reserve were impacted in AYA with AN.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Conclusions: Respiratory acidosis and increased ferritin were common in this group. Respiratory acidosis was the most frequent abnormality with significant pCO2 and HCO3 variation in the recovery phase. VBG should be considered in AN evaluation, once it seems to be important in assessing the severity of the disease and its subsequent follow-up.RESUMO Objetivo: Avaliar a evolu ção laboratorial, particularmente da gasometria venosa, na anorexia nervosa (AN), correlacionando os achados com parâmetros clínicos. Métodos: Estudo retrospetivo com adolescentes com AN seguidos em ambulatório...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
Abstract Endocrine Consequences of Anorexia Nervosa Abstract. Anorexia nervosa is a perilous disease of unknown etiology that causes a variety of endocrine effects. Characteristic for anorexia nervosa are a reduced food intake and thus significant underweight, as well as the fear of gaining weight. Often sufferers also have a distorted self-perception, the urge to move and amenorrhea. AN is difficult to treat and often has a chronic course, and is associated with an increased mortality risk. The endocrinological changes occur in several endocrine axes, their extent is related to the degree of malnutrition. Low lep...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
Rationale: Anorexia nervosa is a chronic psychiatric disease defined by severe weight loss, due to fear of obesity, and self-imposed semi-starvation. Of the many complications following anorexia nervosa, low bone mineral density (BMD) is a significant risk factor for fractures. Anorexia nervosa is associated with higher risk of incident fracture in females across all age groups, and in males>40 years old. Sites at highest risk of fracture include the hip/femur and pelvis in females, and vertebrae in males with anorexia nervosa. Patient concerns: A 29-year-old woman known to have suffered from anorexia nervosa 15...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
We examined 42 healthy female physique athletes (age 27.5 ± 4.0 years, body mass index 23.4 ± 1.7 kg/m2) volunteered into either a diet group (n = 25) or a control group (n = 17). For the diet group, the energy intake was reduced and exercise levels were increased to induce loss of fat mass that was subsequently regained during a recovery period. The control group was instructed to maintain their typical lifestyle, exercise levels, and energy intake at a constant level. For quantification of systems biology markers, fasting blood samples were drawn at three time points: baseline (PRE), at the end of the weigh...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractAnorexia nervosa, a psychiatric disease predominantly affecting women, is characterized by self-induced starvation and a resultant low-weight state. During starvation, a number of hormonal adaptations —including hypothalamic amenorrhea and growth hormone resistance—allow for decreased energy expenditure during periods of decreased nutrient intake, but these very same adaptations also contribute to the medical complications associated with chronic starvation, including low bone mass. Almost 90 % of women with anorexia nervosa have bone mineral density (BMD) values more than one-standard deviation below t...
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research
Conclusion Preclinical and clinical studies have demonstrated that treatment with antipsychotics and metformin had effects on the gut microbiota and the brain. Although the mechanism of the effects of metformin on AIMD remains unclear, there are some clues in the regulation of the gut-brain axis (Figure 1). The most important connections between metformin and AIMD in the gut microbiota were the mucin-degrading bacteria A. muciniphila and several SCFA-producing bacteria, such as the phyla Firmicutes and Bacteroidetes. The gut microbiota were was influenced during AIMD, and these changes included a decrease in A. muciniphil...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Disordered eating behavior and attitudes are common in conditions of functional hypothalamic amenorrhea, such as anorexia nervosa (AN) and exercise-induced amenorrhea (Beals and Hill, 2006; Quah et al., 2009), which are also associated with significant psychiatric co-morbidity, including anxiety and depression. Hypogonadism in these conditions has been implicated in psychological morbidity. Estrogen and progesterone receptors are expressed in appetite regulation centers (e.g., the hypothalamus) and regions regulating emotion and cognition (e.g., the amygdala, ventral tegmental area, insula, and hippocampus) (Campolier et a...
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Source Type: research
Authors: Fazeli PK, Klibanski A Abstract Anorexia nervosa is a psychiatric disease characterized by a low-weight state due to self-induced starvation. This disorder, which predominantly affects women, is associated with hormonal adaptations which minimize energy expenditure in the setting of low nutrient intake. These adaptations include growth hormone resistance, functional hypothalamic amenorrhea and non-thyroidal illness syndrome. Although these adaptations may be beneficial to short-term survival, they contribute to the significant and often persistent morbidity associated with this disorder, including bone los...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
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