Yet Another Blow To Combination Renin-Angiotensin-Aldosterone System Blockade

ACE inhibitors and angiotensin-receptor blockers have been found to effectively slow progression of kidney disease. It has been theorized that dual blockade of the renin-angiotensin-aldosterone system (RAAS) might prove even more beneficial, but these hopes have not been realized. Now a new trial published in the New England Journal of Medicine throws further cold water on the once-promising hypothesis. In the Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) trial, Linda Fried and colleagues randomized type 2 diabetics with proteinuric kidney disease already receiving the angiotensin-receptor blocker losartan to either the ACE inhibitor lisinopril or placebo. The trial was stopped early by the data More…
Source: CardioBrief - Category: Cardiology Authors: Tags: Policy & Ethics Prevention, Epidemiology & Outcomes ace inhibitor Acute kidney injury ARB chronic kidney disease Renal function Source Type: blogs