Methylglyoxal-induced miR-223 suppresses rat vascular KATP channel activity by downregulating Kir6.1 mRNA in carbonyl stress.

CONCLUSION: Vascular KATP channel is important for miR-223 targeting.
SIGNIFICANCE: Regulation of the miR-223 level may be a novel strategy for clinical treatment of diabetes.
PMID: 32151743 [PubMed - as supplied by publisher]

Source: Vascular Pharmacology - March 5, 2020 Category: Drugs & Pharmacology Authors: Jin X, Wu Y, Cui N, Jiang C, Li SS Tags: Vascul Pharmacol Source Type: research