AI can help diagnose bipolar disorder on MRI exams

Artificial intelligence (AI)-based analysis of neuroimaging and neurocognitive...Read more on AuntMinnie.comRelated Reading: What issues are hindering AI's utility in radiology? AI in radiology? Patients are cautiously optimistic AI characterizes complex mood disorders from fMRI Can AI predict treatment response in bipolar patients? MRI links bipolar disease to cerebellum changes
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Publication date: Available online 27 March 2020Source: Journal of Membrane ScienceAuthor(s): Xiaoyun Wu, Hanquan Zhu, Yaoxing Liu, Riyao Chen, Qingrong Qian, Bart Van der Bruggen
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Conclusions: In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS. PMID: 32214520 [PubMed - in process]
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
Conclusion: Lithium pyruvate reduces oxidative DNA damage in the blood of BD patients in vitro, demonstrating the potential of this compound to function not only as a mood stabilizer, but also as an antioxidant and cytoprotector. PMID: 32214518 [PubMed - in process]
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
Conclusions: While this is a very small sample, asenapine appears to have a beneficial effect on both depression and anxiety in depressed bipolar I patients compared to treatment with placebo. Due to the large fraction of subjects with the short form, the hypothesis that the SF-5HTTR might increase asenapine response could not be adequately tested. PMID: 32214517 [PubMed - in process]
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
Publication date: Available online 27 March 2020Source: Journal of Psychiatric ResearchAuthor(s): Hairong He, Chuanyu Hu, Zhenhu Ren, Ling Bai, Fan Gao, Jun Lyu
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This double-blind placebo-controlled, fixed/flexible-dose phase 2 trial assessed the efficacy, safety, and tolerability of cariprazine vs. placebo for depressive episodes associated with bipolar I or II disorder. Primary endpoint was change in Montgomery–Åsberg Depression Rating Scale (MADRS) total scores (baseline to week 8), and secondary endpoint was mean Clinical Global Impressions-Improvement score (week 8). Patients were randomized (N = 233) 1:1:1 to placebo, ‘low-dose’ 0.25–0.5 mg/day or ‘high-dose’ 1.5–3.0 mg/day cariprazine. Adverse events...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
Lithium is an effective agent approved for the treatment of bipolar disorder. It has narrow therapeutic window and significant variability in its pharmacokinetic. The aim of this study is to determine the population pharmacokinetics of lithium in patients with bipolar disorder in Saudi Arabia and to identify the factors that explain variability. A retrospective chart review was performed on patients with bipolar disorder who received oral lithium. The population pharmacokinetic models were developed using Monolix 4.4. After the appropriate base model was established, five covariates were tested, namely age, sex, weight, se...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
Endoscopy DOI: 10.1055/a-1134-4567 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text
Source: Endoscopy - Category: Gastroenterology Authors: Tags: E-Videos Source Type: research
AbstractBipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical Treatment Trial (BETTER). Here, cognitive outcomes of this study are reported. We randomized 59 patients with bipolar disorder I or II in an acute depressive episode to receive active (12 2  mA...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractRecent FindingsIn the last decades, many neuroimaging studies have investigated the brain structural deficits associated with the pathophysiology of Bipolar Disorder (BD). Notably, the available literature identified the presence of selective brain structural abnormalities, in terms of both gray matter (GM) and white matter, known to be involved in emotion regulation and processing. Nonetheless, the complex and heterogeneous nature of BD has not yet allowed the identification of a clear biological signature of this disorder.Purpose of ReviewIn this context, this review aims to a) briefly summarize the evidence from...
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research
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