Dynamics of Ketamine-induced Loss and Return of Consciousness across Primate Neocortex

Conclusions Ketamine generates unique intracortical dynamics during its altered states of consciousness, suggesting fundamentally different neuronal processes from propofol. The gradually shifting dynamics suggest a continuously conscious or dreaming state while unresponsive under ketamine until its deeper stage with the slow-delta oscillations. Somatosensory processing is preserved during ketamine anesthesia, but multisensory processing appears to be diminished under ketamine and through recovery.Editor ’s PerspectiveWhat We Already Know about This TopicKetamine increases both fast and slow oscillations in the primate brain, but the neural correlates of ketamine-induced state transitions have not been precisely characterizedWhat This Article Tells Us That Is NewIn a study of nonhuman primates and continuous ketamine administration, the authors demonstrate a unique and gradual evolution of high-frequency and low-frequency neural activity, which distinguish the effects of ketamine from the dynamics of propofol-induced unconsciousness

Source: Anesthesiology - March 10, 2020 Category: Anesthesiology Source Type: research