A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis.

A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis. Mem Inst Oswaldo Cruz. 2020;115:e190242 Authors: Castellanos IC, Calvo EP, Wasserman M Abstract BACKGROUND: Ubiquitin (Ub) and Ub-like proteins (Ub-L) are critical regulators of complex cellular processes such as the cell cycle, DNA repair, transcription, chromatin remodeling, signal translation, and protein degradation. Giardia intestinalis possesses an experimentally proven Ub-conjugation system; however, a limited number of enzymes involved in this process were identified using basic local alignment search tool (BLAST). This is due to the limitations of BLAST's ability to identify homologous functional regions when similarity between the sequences dips to
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research

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Publication date: Available online 28 May 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Ho Yin Pekkle Lam, Tina Tu-Wen Chen, Yu-Chuan Tseng, Kai-Chih Chang, Ting-Hua Yang, Shih-yi Peng
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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