The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe.
The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe. Microbiology. 2020 Mar 03;: Authors: Strnad M, Rego ROM Abstract Lyme borreliosis is a vector-borne infection caused by bacteria under the Borrelia burgdorferi sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. B. burgdorferi sensu stricto. The whole-genome sequences recently obtained for several European species/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation. PMID: 32125267 [PubMed - as supplied by publisher]
This article presents the proof-of-concept study for a multivalent OspA vaccine targeting a wide range of pathogenic LB Borrelia species with a single recombinant antigen for prevention of Lyme borreliosis.
Borrelia burgdorferi sensu lato, the causative agent of tick-borne Lyme borreliosis (LB), has a limited metabolic capacity and needs to acquire nutrients, such as amino acids, fatty acids, and nucleic acids, from the host environment. Using X-ray crystallography, liquid chromatography-mass spectrometry, microscale thermophoresis, and cellular localization studies, we show that basic membrane protein D (BmpD) is a periplasmic substrate-binding protein of an ABC transporter system binding to purine nucleosides. Nucleosides are essential for bacterial survival in the host organism, and these studies suggest a key role for Bmp...
Publication date: 17 March 2020Source: Cell Reports, Volume 30, Issue 11Author(s): Abdul G. Lone, Troy Bankhead
This study aimed to assess whether the serological history of Borrelia infection was associated with the risk of AF. The study included 113 AF patients and 109 patients in sinus rhythm. All patients underwent a clinical evaluation, echocardiography and had t heir blood taken for the assessment of anti-Borrelia IgG antibodies.
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Conclusions: This study found a high incidence of Lyme disease in Lithuania. We elucidated the baseline characteristics regarding the infected Lithuanian population which may ease medical clinicians' work on new Lyme diagnoses. PMID: 32151097 [PubMed - in process]
Publication date: Available online 2 March 2020Source: Journal of Structural BiologyAuthor(s): Kalvis Brangulis, Inara Akopjana, Ivars Petrovskis, Andris Kazaks, Kaspars Tars
The black-legged (or deer) tick, Ixodes scapularis, commonly infests dogs in the USA and is the vector of important zoonotic pathogens, including Borrelia burgdorferi, the causative agent of Lyme disease. Rapid o...
Publication date: Available online 26 February 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Seunghee Lee, Hyunkyoung Lee, Jung-Won Park, Soon-Seek Yoon, Hyun-Ji Seo, Jinhyeong Noh, Mi-Sun Yoo, Keun-Ho Kim, Yeojin Park, Yun Sang Cho, Byung Jae So
Lyme endocarditis is extremely rare manifestation of Lyme disease. The clinical manifestations of Lyme endocarditis are non-specific and can be very challenging diagnosis to make when it is the only manifestation of the disease. Until now, only a few cases where reported. Physicians should keep in mind the possibility of borrelial etiology of endocarditis in endemic areas. Appropriate valve tissue sample should be sent for histopathology, culture, and PCR especially in case of endocarditis of unknown origin PCR on heart valve samples is recommended. With more frequent PCR, Borrelia spp. may be increasingly found as a cause...