Serum amino acid metabolic profiles of ankylosing spondylitis by targeted metabolomics analysis

ConclusionsThese preliminary results demonstrate that UPLC-TQ-MS analysis method is a powerful tool to identify metabolite profiles of AS. Research in identified disease activity –associated metabolites and biological pathways may provide assistance for clinical diagnosis and pathological mechanism of AS.Key Points• There are perturbations of serum amino acid metabolism in AS, compared with RA and healthy controls, determined by UPLC-TQ-MS.• Metabolomics pathway is used to analysis for the differential metabolites of AS.• The altered serum amino acid could monitor disease activity of AS.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research