Cognitive impairment appears progressive in the mdx mouse

Duchenne muscular dystrophy (DMD) is an X-linked recessive disease, occurring at an incidence of 1 in 3,600-10,000 live male births [1,2]. DMD is characterised by a severe pathology of the skeletal musculature causing progressive loss of muscle, with premature death frequently occurring in the third decade of life as a result of cardiac and respiratory complications [3]. This fatal disease arises from mutations in the DMD gene; the largest gene in the human genome, with 79 exons spanning 2.4 Mb [4], and coding for a 427 kDa intracellular protein named dystrophin [5].

Source: Neuromuscular Disorders - March 2, 2020 Category: Neurology Authors: Emine Bagdatlioglu, Paola Porcari, Elizabeth Greally, Andrew M. Blamire, Volker W. Straub Source Type: research