Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors

ConclusionsPretreatment endosonography-guided biopsy sampling followed by immediate tumor DNA sequencing ofKIT andPDGFRA is highly accurate and valuable in guiding neoadjuvant TKI therapy in GIST. This approach minimizes maltreatment with inappropriate regimens and leads to improved tumor size reduction before surgery.

http://link.springer.com/10.1007/s40291-020-00451-0

Source: Molecular Diagnosis and Therapy - March 1, 2020 Category: Molecular Biology Source Type: research