MiRNAs in endometrioid endometrial cancer metastatic loci derived from positive lymph nodes

ConclusionsCompared to primary endometrioid endometrial cancer tissue, metastatic loci derived from positive lymph nodes are characterised by profound down ‐regulation of miRNA‐204 and miRNA‐424.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

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ConclusionsMetabolomics might be suitable for a non ‐invasive diagnosis and screening of EC, offering the possibility to predict tumor behavior and pathologic characteristics. Further studies are necessary to validate these results.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: SYSTEMATIC REVIEW Source Type: research
ABSTRACTIntroductionThe aims were to evaluate quality of life, cosmetic results and surgical outcomes of robotic single ‐site and robotic multiport total laparoscopic hysterectomy with sentinel lymph node mapping in women treated for low‐ risk endometrial cancer.Material and methodsThe study is a prospective, multicenter, case ‐control study conducted at Ospedale Santa Chiara in Trento and Novara and Pavia University Hospitals. 76 consecutive patients with a biopsy‐confirmed diagnosis of low‐risk endometrial cancer or atypical endometrial hyperplasia who had undergone robotic total laparoscopic hysterectomy and s...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ConclusionsMetabolomics might be suitable for a non ‐invasive diagnosis and screening of EC, offering the possibility to predict tumor behavior and pathologic characteristics. Further studies are necessary to validate these results.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: SYSTEMATIC REVIEW Source Type: research
ABSTRACTIntroductionThe aims were to evaluate quality of life, cosmetic results and surgical outcomes of robotic single ‐site and robotic multiport total laparoscopic hysterectomy with sentinel lymph node mapping in women treated for low‐ risk endometrial cancer.Material and methodsThe study is a prospective, multicenter, case ‐control study conducted at Ospedale Santa Chiara in Trento and Novara and Pavia University Hospitals. 76 consecutive patients with a biopsy‐confirmed diagnosis of low‐risk endometrial cancer or atypical endometrial hyperplasia who had undergone robotic total laparoscopic hysterectomy and s...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Conclusions Although SLN algorithm has an excellent diagnostic value for pelvic nodal metastasis, paraaortic metastasis might be underdiagnosed. 18F-FDG PET/CT may be a feasible tool to exclude paraaortic lymphatic metastasis in high-risk patients for lymphatic metastasis who will undergo SLN algorithm.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
ConclusionsCompared to primary endometrioid endometrial cancer tissue, metastatic loci derived from positive lymph nodes are characterised by profound down ‐regulation of miRNA‐204 and miRNA‐424.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The objective was to assess whether an early response to neoadjuvant chemotherapy in patients with advanced ovarian cancer may predict short ‐ and long‐term clinical outcome.Material and methodsThis is a retrospective study of all patients with stage III ‐IV tubo‐ovarian cancer treated with neoadjuvant chemotherapy at a single center in Montreal between 2003 and 2014. Logistic regression models were used to evaluate the association between cancer antigen 125 (CA‐125) levels during neoadjuvant chemotherapy and debulking success. Cox proportiona l hazard models were used to estimate hazard ratios and their respecti...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
ConclusionsThis study supports the importance of lymphovascular space invasion to identify women with significant risk for recurrence in initially low ‐risk, early‐stage endometrial cancer. It also identifiesCTNNB1 as a significant mutation in early ‐stage disease, and although it may not represent a marker for recurrence its high prevalence in early stage disease could have relevance for both pathogenesis and early treatment.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
We report a case of a postmenopausal female presented with pain and swelling involving right foot. Biopsy revealed metastatic adenocarcinoma. The patient denied any history of vaginal bleeding or other gynecological symptoms. Bone scan suggested increased uptake in multiple tarsal bones. Uterine curettage confirmed the diagnosis of endometrial adenocarcinoma. The patient was successfully treated with debulking surgery, palliative radiotherapy to the right foot, bisphosphonates, and systemic chemotherapy with marked improvement in local symptoms and is under follow-up for the last 6 months after completion of the treatment....
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
The objective of this study was to evaluate a clinically available method of steroid hormone measurement for its prognostic potential in endometrial cancer. METHODS: We quantified seven steroid hormones by liquid chromatography-tandem mass spectrometry in 100 endometrial cancer patients from a prospective cohort. Abdominal fat distribution was assessed from abdominal computed tomography (CT) scans. Steroid hormone levels were compared to clinical characteristics, fat distribution and gene expression in primary tumor samples. RESULTS: Low levels of 17OH-progesterone, 11-deoxycortisol and androstenedione were assoc...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
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