Systematic Review of Patient-Reported Outcome Measures in Graft-versus-Host-Disease

Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after hematopoietic stem cell transplant (HSCT). Traditionally, GVHD was defined as acute and chronic based on time post-transplant, but more recently the 2 are distinguished by clinical and pathophysiologic features [1,2]. GVHD can affect individual organs or can be pleiotropic and can have profound impact on health-related quality of life (QOL) [3]. Chronic GVHD (cGVHD) has been associated with poor functional status, inability to return to work, disrupted activities of daily living, and increased symptom burden [4-6].

Source: Biology of Blood and Marrow Transplantation - February 2, 2020 Category: Hematology Authors: James Kilgour, Gorav Wali, Elizabeth Gibbons, Angela Scherwath, Anna Barata Badiella, Andy Peniket, Helene Schoemans, Rubeta N. Matin, in collaboration with the cGVHD Eurograft Network Source Type: research