Chromogranin A provides additional prognostic information in children with severe hand, foot, and mouth disease: A prospective observational study

Severe hand, foot and mouth disease (HFMD) is associated with high mortality in children, and persistent sympathetic activation is a common presentation. We aim to prospectively investigate serum chromogranin A (CHGA) levels and their prognostic role in this condition.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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This study highlights the importance of appropriate cutaneous sensory feedback to the inte rlimb transfer of strength following unilateral training. AbstractThe relative contribution of cutaneous sensory feedback to interlimb strength transfer remains unexplored. Therefore, this study aimed to determine the relative contribution of cutaneous afferent pathways as a substrate for cross ‐education by directly assessing how “enhanced” cutaneous stimulation alters ipsilateral and contralateral strength gains in the forearm. Twenty‐seven right‐handed participants were randomly assigned to 1‐of‐3 training gr...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Abstract Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excess...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
ConclusionsPsychosocial interventions should address problems of anxiety and depression that people with MDs frequently experience, even through fostering parents ’ and childrens’ engagement coping over disengagement coping.
Source: Journal of Neurology - Category: Neurology Source Type: research
Publication date: Available online 26 March 2020Source: Meta GeneAuthor(s): Omid Daneshjoo, Ali hosseini, Masoud Garshasbi, Antonio Pizzuti
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Conclusion: This represents one of the few cases of Vitelliform Macular Dystrophy with incomplete penetrance, being the first in our country and Latin America, and with our reported mutation with this characteristic. PMID: 32207364 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
 It’s often said that fear is the most dangerous virus on the planet. While a relatively small percentage of people will contract the new coronavirus, or COVID-19, the fear it provokes will chip away at the mental health of nearly everyone who hears about it. So why does COVID-19 inspire so much fear when there are other diseases lurking in the shadows? And what can we do about it? In today’s podcast, our guest Dr. David Batman, a registered medical practitioner in the U.K., discusses how this high level of unprecedented global panic is being intensified by the non-stop media, and specifically, social media....
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Health-related Interview Podcast The Psych Central Show Source Type: blogs
Hemodynamic response during respiration – MCQ – Answer Which of the following is not a normal hemodynamic response during respiration? – Correct Answer: c) Heart rate decreases in inspiration Heart rate increases in inspiration. This is a compensatory reflex in response to the fall in blood pressure during inspiration. Back to question
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Medicine MCQ - CVS Source Type: blogs
BackgroundSome evidence support the notion that microglia activation in acute state of schizophrenia might contribute to damage of oligodendrocytes and myelinated fibers. Previously we found dystrophic changes of oligodendrocytes in prefrontal white matter in schizophrenia subjects displaying predominantly positive symptoms as compared to controls. The aim of the study was to verify whether microglial activation might contribute to dystrophic changes of oligodendrocytes in prefrontal gray matter in this clinical subgroup.MethodsTransmission electron microscopy and morphometry of microglia and adjacent oligodendrocytes were...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China. We performed an observational study involving patients with critical and severe HFMD admitted to the Children's Hospital of Chongqing Medical University from January 2009 to December 2016. Overall, 179 patients aged 2 months to 16 years, were included; 127 died (non-survival group) and 52 survived (survival group); the case-fatality rate was 70.94%. Data comprising demographic characteristics, clinical symptoms and signs, and laboratory findings were collected. Non-conditional logistic regression analysis was...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
It shouldn’t have been a shock when my tooth broke off, but of course, it was. For months, my jaw and teeth have been in a constant state of clenching and grinding. Now, a molar had broken in half, pushed over the edge by one bite of a salted caramel cookie and a steady diet of political news-induced stress. Research shows that as much as 70 percent of bruxism (the medical term for jaw and tooth grinding) occurs as a result of stress and anxiety. For me, the issue started after November’s election, when, like millions of other Americans (or to be exact, 57 percent, according to the American Psychological Associ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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